Non-proliferative Activity of Saponins Isolated from the Leaves of Gymnema Sylvestre and Eclipta Prostrata on Hepg2 Cells- in Vitro Study
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چکیده
The non-proliferative activity of isolated saponins, gymnemagenol (C30H50O4) from Gymnema sylvestre and dasyscyphin C (C28H40O8) from Eclipta prostrata leaves were tested under on HepG2 cells under in vitro conditions. Both gymnemagenol and dasyscyphin C exhibited non-proliferative activity on HepG2 cells at 24 h with the IC50 value of 18.5 and 23.5μg/ml respectively. 5Fluorouracil (5FU) a positive control showed the IC50 value of 1.34μg/ml. The isolated saponins were not toxic to Vero cells. From this study, it can be concluded that the saponins, gymnemagenol and dasyscyphin C have significant non-proliferative activity on HeLa cells under in vitro conditions.
منابع مشابه
Leishmanicidal activity of saponins isolated from the leaves of Eclipta prostrata and Gymnema sylvestre
OBJECTIVE To evaluate the leishmanicidal activity of saponin, dasyscyphin C of Eclipta prostrata and sapogenin, gymnemagenol from Gymnema sylvestre leaves under in vitro conditions. MATERIALS AND METHODS Dasyscyphin C/Gymnemagenol were dissolved in phosphate buffered saline (PBS) and diluted with liquid medium to obtain concentrations ranging from 1000 to 15 mug /ml. The leishmanicidal activi...
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